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FLASH GENE
Symbol ZFYVE16 contributors: mct/npt - updated : 05-06-2019
HGNC name zinc finger, FYVE domain containing 16
HGNC id 20756
EXPRESSION
Type ubiquitous
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Hearing/Equilibriumearinnercochlea highly
Nervousbrain    
 spinal cord    
Urinarybladder   highly
Visualeyeretina   
 eyeuveachoroid  
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Muscularstriatumskeletal highly
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • FYVE zinc finger
  • a protein-phosphatase-binding motif, which functions to negatively modulate BMP signals through receptor dephosphorylation
  • C-terminal half is responsible for interaction with the C-terminal region of TOM1 and for recruitment of TOM1 and clathrin to endosomes
  • HOMOLOGY
    interspecies homolog to C.elegans cosmid D1022
    intraspecies homolog to SARA1
    Homologene
    FAMILY FYVE-domain protein family
    CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endosome
    intracellular,cytoplasm,cytosolic
    basic FUNCTION
  • playing a potential roles in regulating membrane traffic
  • facilitates TGF- signaling as a scaffold protein to promote the R-Smad-Smad4 complex formation by bringing SMAD4 to the proximity of the receptor complex
  • plays an important role in both positive and negative feedback regulation of the BMP signaling pathway, acting a SMAD anchor for receptor activation in BMP signaling
  • plays an important role in both positive and negative feedback regulation of the BMP signaling pathway (Shi 2007)
  • endosome-associated FYVE-domain protein endofin which acts as a Smad anchor for receptor activation in BMP signaling (Shi 2007)
  • possible role of Endofin in the modulation of MAPK pathway
  • is involved in endosomal trafficking and in TGFB1, BMP, and EGFR signaling
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • targeted to early endosomes by its FYVE domain and colocalized with SARA1
  • interacting with TOM1
  • modulates hepcidin through BMP-SMAD signalling
  • ZFYVE16 binds to SMAD4 and their binding affects the formation of SMAD2/3-SMAD4 complex in TGFB1 signaling
  • ZFYVE9, ZFYVE16 recruit the tumor supressor PTPN23, a master regulator of endosomal sorting and ESCRT-dependent receptor downregulation
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS