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FLASH GENE
Symbol SLC27A2 contributors: mct - updated : 30-05-2015
HGNC name solute carrier family 27 (fatty acid transporter), member 2
HGNC id 10996
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveliver   highly
Endocrinepancreas   highly
Nervousbrain   lowly
Urinarykidney   highly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Connectiveadipose   
Epithelialsecretoryglandularendocrine 
cells
SystemCellPubmedSpeciesStageRna symbol
 adipocyte
Digestiveparenchymal
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period pregnancy
Text placenta
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a peroxisome targeting signal 1(-LKL) at C terminus
  • an AMP-binding domain
  • HOMOLOGY
    interspecies homolog to C.elegans d1009.1
    ortholog to rattus Vlcs
    homolog to murine Fatp
    Homologene
    FAMILY
  • long-chain fatty-acid coenzyme A ligase family
  • ATP-dependent AMP-binding enzyme family
  • FATP family of fatty acid uptake mediators
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria
    intracellular,cytoplasm,organelle,lumen
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,peroxisome
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    intracellular,cytoplasm,cytosolic,microsome
    basic FUNCTION
  • playing a key role in lipid biosynthesis and fatty acid degradation
  • multifunctional protein that shows subcellular localization-dependent activity and is a major contributor to peroxisomal very long-chain acyl-CoA synthetase activity and hepatic fatty acid uptake
  • functions in fatty acid transport and activation and has a preference in mediating the channeling of exogenous n-3 fatty acids into phosphatidylinositol
  • even though hypoxia regulates the expression of SLC27A2 and SLC27A4 in trophoblasts
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism lipid/lipoprotein
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    cAMP
    protein
  • RPE65 activity was reduced by co-expression of fatty acyl:CoA ligases (ACSLs) or SLC27A2
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    digestiveliver 
    potential target for treatment of nonalcoholic fatty liver disease (NAFLD) or steatohepatitis (NASH)
    digestiveliver 
    potential novel target for the treatment of nonalcoholic fatty liver disease
    ANIMAL & CELL MODELS