Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol ZNF217 contributors: mct - updated : 20-06-2017
HGNC name zinc finger protein 217
HGNC id 13009
EXPRESSION
Type ubiquitous
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestivemouthtongue  highly
Lymphoid/Immunethymus   highly
Reproductivefemale systembreastmammary gland highly
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • zinc finger motif, C2H2 type, Krueppel-like,
  • with eight zinc finger DNA binding motifs
  • a proline-rich activation domain
  • a typical Pro-X-Asp-Leu-Ser (PXDLS) motif that binds in CTBP1 PXDLS-binding cleft
  • a second motif, Arg-Arg-Thr (RRT), that binds a separate surface on CTBP1
  • conjugated MetalloP
    HOMOLOGY
    Homologene
    FAMILY
  • krueppel C2H2-type zinc-finger protein family
  • CATEGORY transcription factor , protooncogene
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,nucleoplasm
    intracellular,nucleus,chromatin/chromosome
    basic FUNCTION
  • transcriptional repressor protein that functions, at least in part, by associating with CTBP1
  • may play roles in both early- and late-stage breast cancer and can attenuate apoptotic signals resulting from telomere dysfunction as well as from doxorubicin-induced DNA damage
  • may promote neoplastic transformation by increasing cell survival during telomeric crisis and later stages of malignancy by increasing cell survival during chemotherapy
  • implicated with its associated proteins in a novel pathway that may have profound effects on cancer progression
  • transcriptional repressor protein, having, with its associated proteins in a novel pathway, profound effects on cancer progression
  • key factor in regulating ovarian cancer proliferation and progression
  • assembles a distinct set of histone modifying proteins at target DNA sites that act synergistically in transcriptional repression
  • regulates expression of the ERBB3 receptor tyrosine kinase in breast cancer cells
  • implicated as an oncogene and in repressing the E-cadherin gene
  • disruption of active demethylation by the ZNF217 oncogene may be a paradigm for other oncogenic signals on DNA methylation dynamics
  • promoted epithelial-mesenchymal transition (EMT) in mammary epithelial cells, and the TGFB1-activated Smad signaling pathway was identified as a major driver of ZNF217-induced EMT
  • alternatively spliced Kruppel-like transcription factor that has recently been implicated to play a role in carcinogenesis
  • may contribute to ovarian cancer invasion and metastasis, and is associated with worse clinical outcomes
  • orchestrates complex intracellular circuits as a new key regulator of tumorigenesis
  • CELLULAR PROCESS nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    ZNF217 and its associated proteins in a novel pathway that may have profound effects on cancer progression
    a component
  • ZNF217 complex consists of approximately six proteins and contains the transcriptional co-repressors RCOR1, AOS2, histone deacetylase (HDAC) 2 and C-terminal binding protein (CTBP1)
  • INTERACTION
    DNA binding
    RNA
    small molecule metal binding,
  • Zn2+
  • protein
  • actiavating PI3K and AKT for its antiapoptotic activity
  • directly binds to and represses the E-cadherin gene (CDH1) promoter via a two-zinc finger domain that recognizes the consensus
  • is essential for recruitment of the CoREST Complex to the CDKN2B promoter
  • ZNF217/CoREST complex and specific DNMTs combine likely to generate a hypermethylated state resulting in repression of the CDKN2B gene
  • transcriptional repressor that inhibits SLC40A1 expression
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral   amplification --over  
    in breast carcinoma with poor prognosis
    tumoral   amplification    
    in ovarian cancer
    tumoral        
    silencing of ZNF217 resulted in the effective inhibition of ovarian cancer cell growth and invasive ability
    tumoral     --over  
    in primary breast tumours had a higher risk of developing bone metastases
    tumoral     --over  
    promotes prostate cancer growth by restraining SLC40A1-conducted iron egress
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • is a crucial mediator and indicator of bone metastasis
  • ZNF217 mRNA expression may represent a novel prognostic biomarker in breast cancer
  • Therapy target
    SystemTypeDisorderPubmed
    cancermetastases 
    future therapies targeting ZNF217 and/or the BMP signalling pathway may be beneficial by preventing the development of bone metastases
    ANIMAL & CELL MODELS