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FLASH GENE
Symbol LRP3 contributors: npt - updated : 16-11-2006
HGNC name low density lipoprotein receptor-related protein 3
HGNC id 6695
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
blood / hematopoieticspleen   highly
Endocrinepancreas    
Nervousbrain   highly
Reproductivemale systemprostate   
Respiratorylung    
Urinarykidney    
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Epithelialsecretoryglandularendocrine 
Epithelialsecretoryglandularexocrine 
Lymphoid    
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a signal peptide
  • two isoleucine/leucine/value rich regions
  • a RGD sequence
  • two ligand-binding repeat regions TM segments
  • a proline-rich cytoplasmic region
  • HOMOLOGY
    interspecies homolog to rattus lrp3
    intraspecies homolog to low density lipoprotein receptor 3 (LDLR)
    Homologene
    FAMILY
  • low density lipoprotein receptor (LDLR) family
  • CATEGORY receptor membrane
    SUBCELLULAR LOCALIZATION     plasma membrane
    text type 1 membrane protein
    basic FUNCTION
  • receptor mediated endocytosis
  • having a role other than lipoprotein metabolism
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS endocytosis transport
    text receptor mediated endocytosis
    PATHWAY
    metabolism lipid/lipoprotein
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS