basic FUNCTION
| activating clock and PER1 transcription |
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master regulator of circadian rhythm, also playing important roles in the regulation of adipose differentiation and lipogenesis in mature adipocytes |
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required with CLOCK for both circadian transcription and chromatin modification |
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playing an essential role in the generation of the circadian rhythm |
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may be having a role on the differentiation of pre-B cells to mature B cells |
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critical regulator of CDKN1A expression and hepatocyte proliferation |
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CLOCK/ARNTL regulates CCRN4L (nocturnin) transcription through binding to the E-box of nocturnin promoter |
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with CLOCK, are involved in the neuronal differentiation of adult neural stem/progenitor cells which may extend our understanding of various neurological/psychological disorders linked to adult neurogenesis and circadian rhythm |
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ARNTL2, ARNTL form a circadian paralog pair that is functionally redundant |
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with NPAS2 were associated with reproduction and with seasonal variation |
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CLOCK and ARNTL are critical modulators of molecular, cellular, and functional parameters of skeletal muscle |
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important for the regulation of oxidative stress and DNA damage responses, while deregulation of these processes upon ARNTL deficiency leads to development of stress induced senescence |
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circadian variation in S-phase is controlled by ARNTL intrinsic to keratinocytes, because keratinocyte-specific deletion of ARNTL obliterates time-of-day–dependent synchronicity of cell division in the epidermis leading to a constitutively elevated cell proliferation |
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regulates the proportion of cells in S-phase in the interfollicular epidermis and upper follicles |
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CLOCK increases NFKB1–mediated transcriptional activation of responsive promoters independent of its circadian partner ARNTL |
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ARNTL and CLOCK contribute to chromatoid body (CB) assembly and physiology |
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is a positive regulator of myogenesis, which may represent a temporal regulatory mechanism to fine-tune myocyte differentiation |
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expression of clock genes in hair follicles is linked to the circadian rhythm and ARNTL can regulate hair growth |
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DNA methylation of the clock genes, in particular, ARNTL is a key player in the disruption of circadian rhythms that are closely associated with various diseases |
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CLOCK and ARNTL drives rhythmic gene expression and regulate biological functions under circadian control |
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ARNTL and Wnt signalling may have a synergistic effect at a particular stage of osteogenesis |
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"clock" function of MAX is required for maintaining a proper circadian rhythm and MAX and ARNTL contribute to two temporally alternating transcriptional complexes on clock-regulated promoters |