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FLASH GENE
Symbol CELSR3 contributors: mct/shn/pgu - updated : 19-09-2010
HGNC name cadherin, EGF LAG seven-pass G-type receptor 3 (flamingo homolog, Drosophila)
HGNC id 3230
EXPRESSION
Type
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveintestinelarge intestinecolon  
Reproductivefemale systembreast   
Respiratorylung    
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Muscularstriatumskeletal  
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • nine cadherin motifs (CA)
  • seven transmembrane segments (7TM)
  • six EGF-like motifs
  • five Calsium-binding EGF-like domains
  • two laminin G domains (LamG)
  • a Laminin EGF-like domain
  • an hormone binding domain (HRM)
  • a GPCR proteolitic site (GPS)
  • HOMOLOGY
    interspecies ortholog to celsr3, danio rerio
    ortholog to Celsr3, Rattus norvegicus
    ortholog to Celsr3, Mus musculus
    ortholog to CELSR3, Pan troglodytes
    intraspecies homolog to EGFL2
    Homologene
    FAMILY
  • G-protein coupled receptor 2 family
  • LN-TM7 subfamily
  • Flamingo subfamily
  • part of the cadherin superfamily
  • CATEGORY unknown/unspecified , receptor membrane G
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • receptor that may have an important role in cell/cell signaling during nervous system formation
  • involved in contact-mediated communication
  • crucial in axonal tract development
  • mediates interactions between axons and guidepost cells govern axonal tract formation in mammals
  • control ability of facial branchiomotor neurons (FBM neurons) to migrate
  • controls with Celsr2 the development and the function of ependymal cilia in the epithelial lining of cerebral ventricles
  • a key regulator of ciliogenesis in the ependyma
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • mice with inactivated Celsr3 gene display selective anomalies of several major axonal fascicles implicating protocadherins in axonal development
  • null mutation of Celsr3 in mice leads to defective anterior commissure and internal capsule of the axonal tracts
  • Celsr2/Celsr3 double mutant mice display markedly impairment of ependyma and ciliogenesis leading to lethal hydrocephalus