Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol IER3 contributors: mct/npt - updated : 13-11-2009
HGNC name immediate early response 3
HGNC id 5392
EXPRESSION
Type widely
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestivepharynx   highly
Endocrinepancreas    
Hearing/Equilibriumearinnercochlea highly
Nervousnervecranial nerve  highly
Reproductivefemale systemuteruscervix highly
Respiratorylung    
Urinarykidney    
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Blood / Hematopoieticbone marrow   
Epithelialbarrier/lining   
Epithelialsecretoryglandularendocrine 
Epithelialsecretoryglandularexocrine 
cells
SystemCellPubmedSpeciesStageRna symbol
Blood/Hematopoieticmonocyte
Lymphoid/Immunelymphocyte
Muscularmyocyte
Skin/Tegumentkeratinocyte
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • N-linked glycosylation and phosphorylation sites (Shen 2006)
  • HOMOLOGY
    interspecies homolog to C.elegans f56c9.9
    Homologene
    FAMILY
  • IER3 family
  • CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    text
  • type II membrane protein
  • specifically shuttled to and from the nucleus
  • basic FUNCTION
  • inhibiting apoptosis involved in NFKB mediate survival cell and due to FAS or tumor necrosis factor type alpha
  • biomechanically controlled nuclear factor -kappa B target inhibiting cardiomyocyte hypertrophy, counter balancing early hypertrophic responses in activated cardiomyocytes
  • modulates apoptosis, cellular growth, mechanical strain-induced cardiac hypertrophy, and vascular intimal hyperplasia (Kumar 2004)
  • may regulate apoptosis by directly interacting with various proteins involved in the control of apoptotic pathways (Kumar 2004)
  • stress response gene involved in growth control and modulation of apoptosis
  • playing a critical role in regulation of intracellular reactive oxygen species homeostasis (Shen 2006)
  • stress-inducible protein that is involved in the regulation of cell proliferation and apoptosis (Sasada 2008)
  • plays a complex role in the regulation of apoptosis
  • critical role in the NF-kappaB dependent regulation of apoptotic responses
  • CELLULAR PROCESS cell life, antiapoptosis
    PHYSIOLOGICAL PROCESS development
    text embryomic development
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • EPHB2(ERK) substrate having a dual role in EPHB2 signaling by acting both as an EPHB2 downstream effector mediating survival and as a regulator of EPHB2 activation
  • coordinated action of MCL1, IER3, and BCL2L11 controls cell death and survival (new regulatory circuit) (Yoon 2009)
  • interacts with several proteins of which at least four are known to play a role in the regulation of apoptosis (Kumar 2004)
  • cell & other
    REGULATION
    activated by during the early response of cardiomyocytes to hypertrophic stimuli
    induced by ionizing radiation and activators of PRKC
    okadaic acid and tnf-alpha
    12-O tetrade canoylphorbol-13-acetate
    Other monocytes/macrophages differentiation-dependent gene
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in tumor tissues may be associated with a better prognosis in pancreatic cancer (Sasada 2008)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS