basic FUNCTION
| reversibly hydrating CO2 in cellular ion transport and pH homeostasis |
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zinc metalloenzyme responsible for acidification of the microenvironment of cancer cells  |
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CA12 with CA9 are major tumor prosurvival pH-regulating enzymes, and their combined targeting shows that they hold potential as anticancer targets  |
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extracellular enzyme involved in the regulation of the microenvironment acidity and tumor malignant phenotype  |
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may affect the capability of invasion and migration of breast cancer cells, which may be mediated through the MAPK14 pathway  |
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play a central role in osteoclast function and bone remodeling by catalyzing the formation of bicarbonate and proton from carbon dioxide  |
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zinc metalloenzyme that catalyzes the reversible hydration of carbon dioxide to form a bicarbonate anion and a proton  |