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FLASH GENE
Symbol ZBTB22 contributors: KTN - updated : 21-03-2008
HGNC name zinc finger and BTB domain containing 22
HGNC id 13085
EXPRESSION
Type
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart   moderately
Digestiveintestine   moderately
 pancreas exocrine   moderately
 pharynx   predominantly
Nervousbrain   moderately
Reproductivefemale systemuteruscervix moderately
Respiratorylung   highly
Skin/Tegumentskin   moderately
Visualeye   highly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Blood / hematopoieticbone marrow  moderately
cell lineage
cell lines
fluid/secretion moderately in Lymph
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • an N terminal POZ/BTB domain
  • three C terminal zinc finger C2H2 type motifs
  • conjugated MetalloP
    mono polymer heteromer , dimer
    HOMOLOGY
    interspecies homolog to dog ZBTB22 (93.7 pc)
    homolog to chimpanzee ZBTB22 (99.7 pc)
    homolog to rattus Zfp297 (87.1 pc)
    homolog to murine Zbtb22 (87.6 pc)
    Homologene
    FAMILY
  • krueppel C2H2-type zinc-finger protein family
  • CATEGORY regulatory , transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,chromatin/chromosome
    basic FUNCTION
  • acting as a transcriptional regulator
  • acting as a retinoid-X receptor
  • acting as a thyroid hormone receptor coactivator
  • CELLULAR PROCESS nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA binding
    RNA
    small molecule metal binding,
  • Zn2+
  • protein
  • thyroid hormone receptor
  • cell & other
  • retinoic acid receptor
  • vitamin D receptor
  • REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS