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FLASH GENE
Symbol ENTPD3 contributors: mct - updated : 22/11/2008
HGNC name ectonucleoside triphosphate diphosphohydrolase 3
HGNC id 3365
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Endocrineneuroendocrinepituitary  highly
 pancreas   highly
Nervousnerve   highly
Reproductivemale systemprostate   
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Epithelialbarrier/lining   
Epithelialsecretoryglandularendocrine 
Lymphoid    
cells
SystemCellPubmedSpeciesStageRna symbol
Skin/Tegumentkeratinocyte
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • two potential transmembrane segments at the N and C termini
  • four apyrase-conserved regions which is characteristic of NTPases in the N terminal region
  • N-linked glycosylation sites processed to complex oligosaccharides
  • secondary structure five disulfide bonds
    conjugated GlycoP
    HOMOLOGY
    intraspecies homolog to lymphoid cell activation antigen CD39
    Homologene
    FAMILY
    CATEGORY enzyme , antigen
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • cell surface, membrane-bound enzyme hydrolyzing extracellular nucleotides, thereby modulating purinergic signaling
  • invovedd in the control of purinergic signaling, in those cells and tissues expressing both NTPDase3alpha and NTPDase3beta
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    extracellular nucleotides
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS