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FLASH GENE
Symbol PRKAR2A contributors: mct - updated : 15-02-2023
HGNC name protein kinase, cAMP-dependent, regulatory, type II, alpha
HGNC id 9391
EXPRESSION
Type ubiquitous
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestivepancreas exocrine   moderately
Endocrineneuroendocrinepituitary  highly
 parathyroid   highly
Lymphoid/Immunelymph node   moderately
Reproductivefemale systemuteruscervix moderately
 female systembreastmammary gland moderately
 female systemovary  moderately
 male systemtestis  highly
Respiratoryrespiratory tractlarynx  moderately
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Connectiveadipose  moderately
Connectivebone  moderately
cell lineage
cell lines
fluid/secretion highly ion lymph
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • two cyclic nucleotide-binding domains
  • conjugated Other
    mono polymer heteromer , dimer , tetramer
    HOMOLOGY
    interspecies homolog to rattus Prkar2a (89.6 pc)
    homolog to murine Prkar2a (89.2 pc)
    Homologene
    FAMILY
  • cAMP-dependent kinase regulatory chain family
  • CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,cytosolic
    intracellular,cytoplasm,cytoskeleton,microtubule,centrosome
    basic FUNCTION
  • being necessary for cAMP dependent modulation of ion channels
  • mediating membrane association by binding to anchoring proteins, including the MAP2 kinase
  • involved in the regulation of protein amino acid phosphorylation
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS locomotion
    text important for sperm mobility
    PATHWAY
    metabolism
    signaling hormonal , signal transduction
    hormone-mediated signaling
    a component
  • inactive form of the enzyme is composed by two regulatory chains and two catalytic chains
  • active form : two active monomers and a regulatory dimer binding four cAMP
  • INTERACTION
    DNA
    RNA
    small molecule nucleotide,
  • cAMP
  • protein
  • interacting with AKAP4 and CBFA2T3
  • . Ca2+-dependent interaction between S100A1 and PRKAR2A represents a novel mechanism that provides a link between Ca2+ and PKA signaling, which is important for the regulation of gene expression in skeletal muscle via HDAC4 cytosolic-nuclear trafficking
  • cell & other
    REGULATION
    Other inactive form composed of two regulatory chains and two catalytic chains. Activation by cAMP produces two active catalytic monomers and a regulatory dimer that binds four cAMP molecules
    phosphorylated by the activated catalytic chain
    acetylated
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral fusion      
    with RAF1 in melanomas
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • Prkar2a (-/-) and Prkar2a (+/-) mice frequently developed hematopoietic neoplasms dominated by histiocytic sarcomas (HS) with rare diffuse large B cell lymphomas (DLBCL)