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FLASH GENE
Symbol RPL13 contributors: mct - updated : 27-11-2019
HGNC name ribosomal protein L13
HGNC id 10303
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Epithelialbarrier/lining   
cells
SystemCellPubmedSpeciesStageRna symbol
 epithelial cell
cell lineage
cell lines Hela cell
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
highly basic protein with two potential nuclear localization signal (NLS)
HOMOLOGY
Homologene
FAMILY
CATEGORY RNA associated
SUBCELLULAR LOCALIZATION     intracellular
intracellular,cytoplasm,organelle,membrane
intracellular,cytoplasm,organelle,endoplasmic reticulum
intracellular,cytoplasm,cytosolic,ribosome
intracellular,nucleus,nucleolus
text
  • highly expressed in the growth plate and in cells lining the newly primary bone trabeculae
  • basic FUNCTION
  • 60S ribosomal protein 13
  • RPL13 plays an essential role in the progression of some gastrointestinal malignancies
  • DDX3 cooperates with RPL13 to support the assembly of 80S ribosomes for optimal translation initiation of viral mRNA
  • role of RPL13 in bone development
  • could play a specific role in the translation of particular mRNAs in chondrocytes or/and osteoblasts of the growth plate
  • CELLULAR PROCESS protein, translation/synthesis
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component constituent of ribosome,large subunit
    INTERACTION
    DNA
    RNA binding
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) SEMD7
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional       loss of function
    promoted senescence
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • could serve as potential biomarkers of clear cell renal cell carcinoma (ccRCC)
  • Therapy target
    ANIMAL & CELL MODELS