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FLASH GENE
Symbol ATP6V0B contributors: mct - updated : 05-11-2010
HGNC name ATPase, H+ transporting, lysosomal 21kDa, V0 subunit b
HGNC id 861
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveintestinesmall intestine  highly
 stomach   highly
Nervousbrain    
Reproductivefemale systemovary   
 male systemprostate  highly
Respiratorylung    
Skin/Tegumentskin   highly
Visualeye   highly
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES Hydrophobic
STRUCTURE
motifs/domains
  • five putative transmembrane segments (5TM)
  • a conserved glutamic and residue, essential for H+ transporting
  • HOMOLOGY
    interspecies homolog to yeast VMA16
    Homologene
    FAMILY
  • V-ATPase proteolipid subunit family
  • CATEGORY enzyme , transport carrier
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endosome
    intracellular,cytoplasm,organelle,lysosome
    basic FUNCTION
  • ATPase H+ transporting, vacuolar proton pump, microvesicles and other acidic organelles (lysosomes)
  • proton-conducting pore forming subunit of the membrane integral V0 complex of vacuolar ATPase
  • coupling ATP hydrolysis to proton pumping across membranes
  • conserved proton pumps that couple hydrolysis of cytosolic ATP to proton transport out of the cytosol
  • important role for physical association between aldolase and V-ATPase in the regulation of the proton pump
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS electron transport
    PATHWAY
    metabolism energetic
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS