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FLASH GENE
Symbol PLS1 contributors: mct - updated : 01-04-2016
HGNC name plastin 1 (I isoform)
HGNC id 9090
EXPRESSION
Type
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveintestinesmall intestine  highly
 intestinelarge intestinecolon  
 liver    
 stomach   lowly
Respiratorylung   lowly
Urinarykidney    
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Epithelial    
cells
SystemCellPubmedSpeciesStageRna symbol
 epithelial cell
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • two actin-binding domains,
  • four calponin-homology (CH) domains
  • two EF-hand calcium-binding domains
  • conjugated PhosphoP
    mono polymer monomer
    HOMOLOGY
    interspecies ortholog to murine Pls1
    homolog to Drosophila Fim
    homolog to C.elegans Y104H12BR.1
    Homologene
    FAMILY family of actin-binding proteins
    CATEGORY structural protein
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,cytoskeleton
    text brush border of small intestine
    basic FUNCTION
  • acting as an actin-bundling protein in the absence of calcium
  • along with villin and espin is a prominent actin-bundling protein of the intestinal brush border microvilli
  • emerges as an important regulator of brush border morphology and stability through a novel role in the organization of the terminal web, possibly by connecting actin filaments to the underlying intermediate filament network
  • in contrast to other actin-bundling proteins such as ESPN, USH1C or EPS8, PLS1 is dispensable for the initial formation of stereocilia
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding,
    calcium Ca2+
    protein
  • binding to actin
  • interacts with KRT19, possibly contributing to anchoring the rootlets to the keratin network
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • plastin 1-deficient mice have conspicuous ultrastructural alterations: microvilli are shorter and constricted at their base, and, strikingly, their core actin bundles lack true rootlets