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FLASH GENE
Symbol HESX1 contributors: mct/npt/pgu - updated : 03-01-2013
HGNC name HESX homeobox 1
HGNC id 4877
EXPRESSION
Type restricted
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveintestine    
Reproductivefemale systemuterus   
 female systemovary   
cell lineage ES (embryonic stem) cells
cell lines
fluid/secretion
at STAGE
physiological period embryo
Text anterior extreme of the rostral neural, in the developing anterior pituitary fold, olfactory placode, prechordal in Rathke's pouch
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • helix-turn-helix, DNA binding domain, homeodomain
  • mono polymer heteromer , dimer
    HOMOLOGY
    interspecies homolog to murine embryonic stem cells
    Homologene
    FAMILY
  • ANF homeobox family
  • CATEGORY DNA associated , transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • involved in normal development of the forebrain, eyes and other anterior and midline structures (olfactory placodes and pituitary gland)
  • RNA polymerase 2 transcription factor, repressor of PROP1-mediated gene stimulation
  • might play a role in the maintenance of the anterior pituitary cell types and function, as well as in the differentiation of pituitary adenomas
  • required to establish binding to a portion of the N-terminus of DNMT1 and its catalytic domain in the C-terminus
  • conserved vertebrate-specific transcription factor that is required for forebrain development
  • novel function in mediating repression of Wnt/CTNNB target activation in the developing forebrain
  • CELLULAR PROCESS nucleotide, transcription
    PHYSIOLOGICAL PROCESS development
    PATHWAY
    metabolism
    signaling
    a component
  • formation of a heterodimer between HESX1 and PROP1 provides a condition in which, in the early pituitary primordium, HESX1 alters its repressive role to an active one by forming a heterodimer with newly appearing PROP1 so that PROP1 finally replaces HESX1 to advance to the middle stage of pituitary development
  • INTERACTION
    DNA binding
    RNA
    small molecule
    protein
  • interacting with OTX2
  • interacting with DNMT1 (HESX1-DNMT1 complexes co-localise in the nucleus, suggesting a novel mechanism for the repressing properties of HESX1)
  • in the presence of PROP1, HESX1 develops to bind to an inverted TAAT motif by forming a heterodimer
  • possible synergistic gene dosage-dependent interaction between HESX1 and TCF3, a transcriptional repressor of Wnt target genes, to maintain anterior forebrain identity
  • cell & other
    REGULATION
    repressed by during pituitary organogenesis
    ASSOCIATED DISORDERS
    corresponding disease(s) SOPT , APIT
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • mouse embryos deficient for Hesx1 exhibit a variable degree of forebrain defects