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FLASH GENE
Symbol BCL9 contributors: - updated : 28-02-2007
HGNC name B-cell CLL/lymphoma 9
HGNC id 1008
EXPRESSION
Type ubiquitous
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Nervousnervecranial nerve   
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Connectiveadipose   
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • large proline-rich protein containing a potential nuclear localization signal (NLS)
  • HOMOLOGY
    interspecies ortholog to murine Bcl9
    Homologene
    FAMILY
    CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • involved in translocation t(1;14) and t(1;22)
  • involved in signal transduction through the Wnt pathway, promoted beta-catenin's transcriptional activity
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    Wnt receptor signaling pathway
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • PYGO1
  • PYGO2
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral   translocation    
    B-cell malignancies with abnormalities of chr 1q21
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS