Selected-GenAtlas references	SOURCE	GeneCards	NCBI Gene	Swiss-Prot	Ensembl
	HGNC	UniGene	Nucleotide	OMIM	UCSC

Home Page

FLASH GENE

Symbol

ELF1

contributors: mct/ - updated : 09-05-2018

HGNC name	E74-like factor 1 (ets domain transcription factor)
HGNC id	3316

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

EXPRESSION

Type	ubiquitous

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Lymphoid/Immune lymph node       highly Respiratory respiratory tract trachea     highly

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Blood / hematopoietic bone marrow     highly

cell lineage	lymphoid and myeloid cells
cell lines
fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	a N terminal A transactivation domain
	a central AT hook domain
	a C terminal ETS DNA binding protein

HOMOLOGY

interspecies

homolog to C.elegans c30b5.1

Homologene

FAMILY

ETS family

CATEGORY

regulatory , transcription factor

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm
	intracellular,nucleus

basic FUNCTION	involved in the transcriptional regulation of several hematopoietic cell genes
	regulating vascular-specific gene expression during blood vessel development
	transcriptional regulator of TEK
	required for the T-cell-receptor-mediated trans activation of HIV-2 gene expression
	involved in transcriptional activation of PYGO2
	involved in T cell development and function

CELLULAR PROCESS

nucleotide, transcription

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA	binding to both Ets binding sites (EBS1,EBS2) of IL2 enhancer

RNA

small molecule

protein	binding to RB1 in resting normal T cells
	in the nucleus, binds to the promoter of the TCR zeta gene and promotes its transcription in Jurkat and fresh T cells
	interacting with GATA3
	interaction with LAT (overexpression of ELF1 augments LAT promoter activity)
	an important positive regulator of MEIS1 expression
	FLI1, ELF1, and GABPA regulate PF4 gene expression through the -51 ETS site in megakaryocytes and implicate the differentiation stage-specific regulation of PF4 gene expression by multiple ETS factors
	ELF1 binds an important duplicated GGAA cis-acting element at the OAS1 promoter and in cooperation with RB1 and SP1 recruitment contributes to regulation in response to IFN stimulation

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function constitutional     --low   with decreased TCR zeta chain gene expression in patients with systemic lupus erythematosus

Susceptibility

to systemic lupus erythematosus

Variant & Polymorphism other	polymorphisms increasing the risk of systemic lupus erythematosus

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS