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FLASH GENE
Symbol EPX contributors: mct - updated : 29-11-2017
HGNC name eosinophil peroxidase
HGNC id 3423
EXPRESSION
Type restricted
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Lymphoid/Immunethymus    
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Blood / hematopoieticbone marrow   
Connectivebone   
cells
SystemCellPubmedSpeciesStageRna symbol
Blood/Hematopoieticeosinophil Homo sapiens
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
mono polymer tetramer
HOMOLOGY
Homologene
FAMILY peroxidase family, XPO subfamily
CATEGORY enzyme
SUBCELLULAR LOCALIZATION extracellular
    intracellular
intracellular,cytoplasm,cytosolic,granule
text localized in cytoplasmic granules of eosinophils
basic FUNCTION
  • having significant inhibitory activity towards Mycobacterium tuberculosis H37Rv
  • abundant heme protein in eosinophils that catalyzes the formation of cytotoxic oxidants implicated in asthma, allergic inflammatory disorders, and cancer
  • EPX-dependent oxidative damage may play a role in tissue injury in bisulfite-exacerbated eosinophilic inflammatory disorders
  • prodction and storage of the two ancestral proteins, RNASE3 and EPX likely share common regulatory mechanisms,
  • which result in opposing productions of the two proteins
  • preferential role of EPX signaling via a specific surface receptor that leads to neural plasticity
  • important and previously unsuspected role for MPO and EPX as drivers of angiogenesis
  • MPO and eosinophil peroxidase (EPX) are heme-containing enzymes, well known for their antimicrobial activity, that are released in abundance by innate immune infiltrates at sites of inflammation and injury
  • peroxidase enzymes, like MPO and EPX, may play a fundamental role in inhibiting TNFSF11-induced osteoclast differentiation at inflammatory sites of bone fracture and injury
  • EPX and MPO are key contributors to cancer progression by augmenting pro-tumorigenic collagen production and angiogenesis
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component tetramer of two light chains and two heavy chains
    INTERACTION
    DNA
    RNA
    small molecule metal binding,
    binds 1 calcium ion per heterodimer
    protein
  • EPX is a novel ligand for the ERBB2
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) EPXD
    Susceptibility to inflammatory bowel disease (IBD)
    Variant & Polymorphism other
  • polymorphisms of EPX are associated to IBD in an age and gender dependent manner, suggesting an essential role of eosinophils in the pathophysiology of IBD
  • Candidate gene
    Marker
  • EPX-based ELISA is a valid, reliable, repeatable, and specific surrogate marker of eosinophils and/or eosinophil degranulation in the sputum of respiratory patients
  • Therapy target
    SystemTypeDisorderPubmed
    immunologyinflammatory 
    peroxidase inhibitors may have therapeutic potential for the treatment of angiogenesis related diseases driven by inflammation
    ANIMAL & CELL MODELS