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FLASH GENE
Symbol MNT contributors: mct/npt - updated : 09-09-2009
HGNC name MAX binding protein
HGNC id 7188
EXPRESSION
Type restricted
   expressed in (based on citations)
organ(s)
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period embryo
Text restricted to embryonic tissues
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • two highly conserved domains, Sin3-interacting domain (SID)
  • and basic helix-loop-helix leucine zipper domain (bHLHzip), which are essential for the function during molecular switching from proliferation to differentiation (Guo 2007)
  • HOMOLOGY
    Homologene
    FAMILY
  • Myc/Mad family of transcription factors
  • CATEGORY transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • acting as a transcriptional repressor in an E.box driver reporter gene repression system through interaction between the N-terminus and SIN3 corepressor, potentially involved in proliferation and differentiation
  • antagonize the function of MYC
  • switch from MNT to MYC during bile duct ligation is responsible for the induction in TP53 and cyclin D1 expression and contributes to apoptosis (
  • CELLULAR PROCESS nucleotide, transcription
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA binds DNA as an homodimer or a heterodimer with MAX
    RNA
    small molecule
    protein
  • Max interactor 2 (interacting with Max to bind Myc-Max recognition sites)
  • MYC and MNT use MAX as a cofactor for DNA binding
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral somatic mutation      
    in acute leukaemia (Guo 2007)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS