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FLASH GENE
Symbol SELE contributors: mct - updated : 03-01-2013
HGNC name selectin E (endothelial adhesion molecule 1)
HGNC id 10718
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart    
Digestiveliver    
 mouth   highly
Endocrineparathyroid   highly
Respiratorylung    
 respiratory tracttrachea  highly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Epithelialbarrier/lining   
Muscularstriatumskeletal  
cells
SystemCellPubmedSpeciesStageRna symbol
Cardiovascularendothelial cell
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • N terminal C-type lectin domain
  • an EGF-like motif
  • six short consensus repeats, sushi structure
  • six conserved cysteines per repeat
  • a short cytoplasmic tail
  • HOMOLOGY
    interspecies homolog to murine Sele
    Homologene
    FAMILY Selectin/Lecam family
    CATEGORY adhesion
    SUBCELLULAR LOCALIZATION extracellular
        plasma membrane
        intracellular
    intracellular,cytoplasm,cytoskeleton
    intracellular,nuclear envelope
    text type 1 membrane protein
    basic FUNCTION
  • participating in the interaction between leukocytes and the endothelium and may be involved in the pathogenesis of atherosclerosis
  • plays critical roles in tethering leukocytes to endothelial cells (ECs)
  • pivotal molecule for endothelial progenitor cells homing to ischemic limb and vasculogenesis
  • during inflammation, SELE-expressed on cytokine-activated endothelial cells mediates leukocyte rolling under flow
  • SELE clusters in both clathrin-coated pits and lipid rafts of endothelial cells but is internalized in clathrin-coated pits
  • expressed by cardiac fibroblasts with ICAM1 and CXC chemokines in response to proinflammatory cytokine stimulation in the infarcted myocardium
  • might be an important factor involved in the process of cerebral aneurysm formation and rupture, by promoting inflammation and weakening cerebral artery walls
  • role of endothelial cell adhesion molecules SELP, SELE and ICAM1 in leucocyte recruitment induced by exogenous methylglyoxal in diabetes
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • HOXA9 acts as an obligate proinflammatory factor by mediating cytokine induction of SELE
  • CD40/CD40L interaction induces SELE-dependent adhesion of leukocytes to endothelial cells and reduces endothelial cell migration
  • MUC16 is the SELE and SELL ligand expressed by metastatic pancreatic cancer cells
  • stimulus-dependent methylation of HOXA9 is essential for SELE expression during the endothelial cells inflammatory response
  • ADRB3 stimulation acts through up-regulation of SELE in adipose tissue endothelial cells to induce neutrophil infiltration
  • cell & other
    REGULATION
    induced by IL1B,TNFA
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --over  
    reduced leucocyte rolling velocity
    constitutional     --over  
    in patients with hereditary angioedema, during inter-attack periods
    Susceptibility
  • to atherosclerosis
  • to essential hypertension
  • to pancreatic cancer development
  • Variant & Polymorphism other
  • mutations of the gene may be a risk factor in atherosclerosis
  • S128R "C" allele may confer an increased susceptibility to pancreatic cancer development
  • Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS