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FLASH GENE
Symbol GAS2 contributors: - updated : 02-06-2007
HGNC name growth arrest-specific 2
HGNC id 4167
EXPRESSION
Type ubiquitous
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestivesalivary gland   highly
Lymphoid/Immunespleen   highly
 thymus   highly
Respiratorylung    
Urinarykidney    
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
intraspecies homolog to GAR22
Homologene
FAMILY maybe same family as GAR22
CATEGORY signaling growth factor
SUBCELLULAR LOCALIZATION     intracellular
intracellular,cytoplasm
basic FUNCTION
  • plays a role in regulating microfilament and cell shape changes during apoptosis
  • may play a role in apoptosis by acting as a cell death substrate for caspases
  • may enhance TP53 stability by inhibiting calpain activity
  • CELLULAR PROCESS cell cycle
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • caspase-3 substrate that plays a role in regulating microfilament and cell shape changes during apoptosis
  • interacts with m-calpain inhibits calpain-dependent processing of TP53
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS