SUBCELLULAR LOCALIZATION
| intracellular
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| intracellular,cytoplasm,organelle,endoplasmic reticulum
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| intracellular,nucleus,nucleoplasm
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| predominantly a nuclear protein, and it can translocate to the cytoplasm during apoptosis |
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nucleocytoplasmic shuttling protein with a diverse array of functions, including an ability to modulate the cytoskeletal compartment by binding to microtubule-associated proteins |
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prominently located within the nuclei of hepatocytes |
basic FUNCTION
| nucleoplasmic shuttling protein involved in several processes such as regulation of gene expression, RNA transport, apoptosis, intracellular signaling and cytoskeletal dynamics |
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protein-protein interactions, may be involved in signal transduction or in RNA processing |
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heat stable protein phosphatase 2A inhibitor |
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regulator of the apoptosis response of cancer cells and predictor of survival following chemotherapy for advanced non small cell lung cancer |
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apoptotic enhancer that stimulates apoptosome-mediated caspase activation |
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directly regulates expression of the neurofilament light chain, an important neuron-specific cytoskeletal gene, by binding to the promoter of this gene and modulating histone acetylation levels |
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nuclear protein with the ability to promote liver regeneration |
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is potentially involved in the formation of IFN-stimulated genes (ISGs) transcription initiation complexes, possibly as their recruiter |
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with other ANP32 proteins have been implicated in a broad array of physiological processes, including cell differentiation, apoptotic cell death, and cell proliferation |
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mediates neuritic pathology in Spinocerebellar ataxia type 1 |
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attenuated oxidative injury and fibrosis induced by ethanol feeding and the SPHK1/S1P/S1PRs signalling pathway contributes to the protective effect of HPPCn on hepatocyte apoptosis |
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ANP32A, ANP32B, ANP32E represent an important node of physiological regulation by virtue of their diverse biochemical activities |