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FLASH GENE
Symbol PSMC6 contributors: mct - updated : 01-07-2014
HGNC name proteasome (prosome, macropain) 26S subunit, ATPase, 6
HGNC id 9553
EXPRESSION
Type ubiquitous
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestivesalivary gland   highly
Endocrineparathyroid   highly
Reproductivefemale systemuterus  highly
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • C terminus with non-HbYX motif is essential for cellular 26 S proteasome assembly
  • HOMOLOGY
    Homologene
    FAMILY PSM, proteasome family, triple-A family of ATPases
    CATEGORY chaperone/stress , enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    intracellular,nucleus,nucleoplasm
    basic FUNCTION
  • 19/22S regulator of proteasome p42, ATPase subunit, involved in the ATP-dependent degradation of ubiquitinated proteins
  • direct target of transcriptional activation domains in the 26S proteasome
  • proteasome subunit enriched at telomeres and at genes transcribed by RNA polymerase III
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component component 26S (prosome-macropain) of multicatalytic proteinase complex of proteasome
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • FLCN and PSMC6 interaction may be evolutionarily conserved between flies and humans
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    tumor  
    PSMC6 inhibition may present a novel methodology to inhibit tumor development in Birt-Hogg-Dubé tumor
    ANIMAL & CELL MODELS