basic FUNCTION
| dioxin receptor translocator, activating genes involved in metabolism, angiogenesis and apoptosis |
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functions as an estrogen receptor beta-selective coactivator |
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functions in concert with RELB in a TNFRSF8-induced negative feedback mechanism |
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basic helix-loop-helix Period/ARNT/Single-minded (bHLH-PAS) protein that controls various biological pathways as part of dimeric transcriptional regulator complexes with other bHLH-PAS proteins |
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acts as a modulator to bridge the JUN/SP1 interaction and plays a role in EGF-mediated gene expression under normoxic conditions |
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important role for ARNT in anaplerosis, and it may play a critical role in maintaining normal secretion competence of pancreatic beta-cells |
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important regulator of hepatocellular carcinoma growth and metastasis |
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regulates glucose uptake, mitochondrial gene expression, and vascular permeability to control adipose mass and function, providing a target for obesity therapy |
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dioxin-independent co-activator/co-repressor function for ARNT in estrogen signalling |
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redistribution of ARNT from nucleus to cytoplasm involved in suppression of the hypoxia inducible factor-1 function |