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FLASH GENE
Symbol CCR9 contributors: mct - updated : 12-07-2007
HGNC name chemokine (C-C motif) receptor 9
HGNC id 1610
EXPRESSION
Type
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveintestinesmall intestine  highly
Lymphoid/Immunelymph node   lowly
 spleen   lowly
 thymus   specific
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Lymphoid    
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
seven transmembrane segments (7TM) receptor
conjugated GlycoP
HOMOLOGY
interspecies homolog to rattus Ccr9 (86.5 pc)
homolog to murine Ccr9 (85.6 pc)
Homologene
FAMILY
  • G protein coupled receptor superfamily (family 1)
  • beta chemokine receptor family
  • CATEGORY immunity/defense , receptor membrane G
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • acting as a specific receptor for chemokine SCYA25/TECK
  • transducing subsequently a signal by increasing the intracellular calcium ions level
  • acting as a alternative coreceptor with CD4 for HIV-1 infection
  • acting as a rhodopsin-like receptor
  • CELLULAR PROCESS cell communication
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling signal transduction
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    induced by TLR2 ligands that induce CCR9 and CCR10 expression by circulating B cells and increased chemotaxis to cognate chemokines CCL25 and CCL28
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS