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FLASH GENE
Symbol NDUFS4 contributors: mct - updated : 29-09-2010
HGNC name NADH dehydrogenase (ubiquinone) Fe-S protein 4, 18kDa (NADH-coenzyme Q reductase)
HGNC id 7711
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveliver    
Endocrinepancreas    
Nervousbrain    
Reproductivemale systemprostate   
Respiratorylung    
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period fetal
Text pancreas
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • extrinsic domain, mitochondrial signal peptide
    • secondary structure seven subunit mitochondrial, 34 subunit nuclear, forty different subunits
    mono polymer polymer
    isoforms Precursor precursor of 18kDa
    HOMOLOGY
    interspecies homolog to murine Ndufs4
    Homologene
    FAMILY
  • complex I NDUFS4 subunit family
    • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria,inner
    intracellular,cytoplasm,organelle,membrane
    intracellular,nucleus
    basic FUNCTION
  • NADH ubiquitine dehydrogenase (Q reductase), assembly of a functional complex 1
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • component of complex I multi-subunit enzyme of the oxidative phosphorylation (OXPHOS)
    • INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) NDUFS4 , CMTND1
    related resource MITOP database
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS