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FLASH GENE
Symbol KIF3C contributors: mct - updated : 28-09-2017
HGNC name kinesin family member 3C
HGNC id 6321
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart    
Digestiveliver    
Endocrinepancreas    
Nervousbrain   highly Homo sapiens
Reproductivemale systemprostate   
Respiratorylung    
Visualeyeretina  highly
cells
SystemCellPubmedSpeciesStageRna symbol
Nervousneuron Homo sapiens
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • N terminal globular domain, the motor domain with an ATP and the microtubule binding sites
  • a long alpa-helical coiled-coil region (stalk region), involved in dimerization
  • a small C terminal domain, potentially involved in interaction with other proteins, vesicles or organelles
  • mono polymer heteromer , dimer
    HOMOLOGY
    interspecies ortholog to murine Kif3c
    homolog to Drosophila Klp68D
    homolog to C.elegans klp-11
    Homologene
    FAMILY
  • kinesin-like protein family of microtubule-associated motor proteins
  • kinesin II subfamily
  • CATEGORY motor/contractile
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    intracellular,cytoplasm,cytoskeleton,microtubule
    basic FUNCTION
  • acting as microtubule-based anterograde translocator for membranous organelles
  • playing a role in various intracellular transport and spindle formation
  • KIF3B mutant photoreceptor cilia differentiate with a delay, suggesting that KIF3C, although redundant with KIF3B at later stages of differentiation, is not active early in photoreceptor ciliogenesis
  • is a key regulator of axonal growth and regeneration by controlling microtubule dynamics and organization in the growth cone
  • KIF3C is an injury-specific kinesin that contributes to axon growth and regeneration by regulating and organizing the microtubule cytoskeleton in the growth cone
  • functions as a motor protein involved in axonal transport in neuronal cells
  • KIF3A, KIF3B, KIF3C is classified as a heterotrimeric kinesin-2 that is best known for organelle transport in neurons
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    text non-selective vesicle transport
    PATHWAY
    metabolism
    signaling
    a component
  • heterodimer of KIF3A and KIF3C
  • intermolecular communication within the KIF3AC heterodimer modulates entry into the processive run regardless of whether the run is initiated by the KIF3A or KIF3C motor domain
  • INTERACTION
    DNA
    RNA
    small molecule nucleotide,
    ATP
    protein
  • FMR1-interacting protein (FMR1 is a molecular adaptor between the neurospecific KIF3C kinesin and dendritic RNA granules)
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    of KIF3C in breast cancer may be associated with the tumor progression and metastasis
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS