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FLASH GENE
Symbol CRIP1 contributors: mct/npt - updated : 07-07-2010
HGNC name cysteine-rich protein 1 (intestinal)
HGNC id 2360
EXPRESSION
Type restricted
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveintestinesmall intestine  highly
Lymphoid/Immunespleen   highly
 thymus   highly
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period fetal, pregnancy
Text heart, liver at the early pregnancy
PROTEIN
PHYSICAL PROPERTIES basic
STRUCTURE
motifs/domains
  • a double zinc finger motif (LIM domains)
  • a glycine rich domain
  • HOMOLOGY
    interspecies homolog to murine Crip
    Homologene
    FAMILY
  • LIM/double zinc finger protein family
  • cysteine-rich intestinal protein family
  • CATEGORY transport carrier
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytoskeleton
    basic FUNCTION
  • playing a role in processes of cellular repair (located in a region of multiple breakpoint)
  • playing a role in zinc absorption and functioning as an intracellular zinc transport protein (zinc carrier protein)
  • playing a role in a cellular pathway that produces an imbalance in cytokine pattern favoring Th2 cytokines (Lanningham-Foster 2002)
  • actin cytoskeleton-interacting LIM-domain proteins known to act in muscle cell differentiation (Latonen 2008)
  • stress response factor, having growth-inhibitory and cytoprotective functions (Latonen 2008)
  • CELLULAR PROCESS cell life, differentiation
    cell life, proliferation/growth
    PHYSIOLOGICAL PROCESS immunity/defense , cellular trafficking transport
    text anti-microbial humoral response
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding,
  • Zn2+ (2 ions bound by the LIM domain)
  • protein
  • filamentous actin cross-linker alpha-actinin
  • cell & other
    REGULATION
    induced by growth-inhibitory signals, such as increased cellular density, and cytotoxic stress induced by UV radiation or staurosporine (Latonen 2008)
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    by hypomethylation in prostate cancer (Wang 2007)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS