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FLASH GENE
Symbol GRIN2D contributors: mct - updated : 16-11-2016
HGNC name glutamate receptor, ionotropic, N-methyl D-aspartate 2D
HGNC id 4588
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Nervousbrainmidbrainsubstantia nigra predominantly Homo sapiens
 brainbasal nucleiglobus pallidus predominantly Homo sapiens
 braindiencephalonhypothalamussuprachiasmatic nucleimoderately Homo sapiens
 brainbasal nucleistriatum predominantly Homo sapiens
 brainlimbic systemhippocampus highly Mus musculus
Reproductivefemale systembreastmammary gland highly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Connectivebone   
Nervouscentral   
Nervousperipherous   
cells
SystemCellPubmedSpeciesStageRna symbol
Nervousneuron
Skin/Tegumentkeratinocyte Homo sapiens
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • four transmembrane domains
  • conjugated GlycoP
    mono polymer heteromer , dimer
    HOMOLOGY
    interspecies ortholog to rattus Grin2d
    ortholog to murine Grin2d
    Homologene
    FAMILY
  • glutamate-regulated family of ion channels
  • CATEGORY receptor membrane , transport channel
    SUBCELLULAR LOCALIZATION     plasma membrane,junction
    text
  • postsynaptic membrane
  • selective to asymmetrical synapses of GABAergic neurons
  • basic FUNCTION
  • involved in excitatory neurotransmission and in neuronal cell death
  • playing a central role in long potentiation, verbal long potentiation memory and cognitive function
  • ligand-gated ion channel (Ca2+) transporting, when bound to glutamate and Mg2+ released
  • activity of the GRIN1/GRIN2D NMDA receptor is controlled distinctively by the endogenous neurotransmitter L-glutamate
  • role for GRIN2D-containing NMDARs and adaptive changes in experimental Parkinsonism
  • GRIN2B, GRIN2D play counteractive roles in temporal development and maturation of somatosensory maps without affecting the magnitude of critical period plasticity
  • GRIN2B expressed at glutamatergic synapses on glutamatergic projection neurons facilitates refinement of ascending pathway synapses directly, whereas GRIN2D expressed at glutamatergic synapses on GABAergic interneurons delays it indirectly
  • role for GRIN2D in endothelial function and angiogenesis
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS development , nervous system
    text
  • ion transport
  • PATHWAY
    metabolism
    signaling neurotransmission
    a component
  • heterodimerizing with GRIN1
  • N-methyl D-aspartate receptor 2, epsilon 4 subunit glutamate receptor
  • heteromers composed of the key receptor subunit GRIN1 and one or more of the four NMDAR2 subunits (GRIN2A, GRIN2B, GRIN2C, GRIN2D)
  • GRIN2D-containing NMDARs participate likely in excitatory synaptic transmission onto hippocampal interneurons
  • INTERACTION
    DNA
    RNA
    small molecule metal binding,
  • Mg2+
  • Ca2+
  • protein
  • PLAT influences spatial memory through its preferential interaction with GRIN2D subunit-containing NMDARs
  • DOCK3, a guanine nucleotide exchange factor, binds to the GRIN2D C-terminal domain and reduces the surface expression of GRIN2D, thereby protecting retinal ganglion cells (RGCs) from excitotoxicity
  • cell & other
    REGULATION
    activated by the artificial glutamate analog N-methyl D-aspartate (selectively)
    ASSOCIATED DISORDERS
    corresponding disease(s) EIEE46
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional       loss of function
    GRIN2B and GRIN2D-deficiency protected retinal ganglion cells (RGCs) from NMDA-induced excitotoxic retinal cell death
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • its expression was shown be predictive of improved survival in CRC
  • Therapy target
    SystemTypeDisorderPubmed
    cancerdigestivecolon
    promising target for the future treatment of colorectal cancer
    neurologyneurodegenerativeParkinson/dementia Parkinsonism
    may represent potential therapeutic targets for modulating subthalamic neuron activity in neurological disorders such as Parkinson disease
    neurologyneurodegenerativealzheimer
    GRIN2D and DOCK3 might be potential therapeutic targets for treating neurodegenerative diseases such as Alzheimer disease
    neurosensorialvisual 
    GRIN2D and DOCK3 might be potential therapeutic targets for treating normal tension glaucoma
    ANIMAL & CELL MODELS
    Nmdar 2d knock out mice