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FLASH GENE
Symbol MARK3 contributors: mct/pgu - updated : 21-08-2010
HGNC name MAP/microtubule affinity-regulating kinase 3
HGNC id 6897
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart   highly
Digestivemouthtongue  highly
Nervousbrain   highly
Reproductivefemale systemuterus  highly
 male systemtestis  highly
Respiratorylung   highly
 respiratory tractlarynx  highly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Blood / hematopoieticbone marrow   
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period growth/childhood
Text placenta
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a conserved N-terminal kinase domain
  • a conserved region of about 40 amino acids at their extreme C-termini, with a ubiquitin-associated (UBA) domain located C-terminal to the kinase domain, forming a stable intramolecular interaction with the N-terminal lobe of the kinase domain (Murphy 2007), and a highly conserved C-terminal domain, which has been termed kinase-associated domain-1 (KA-1)
  • HOMOLOGY
    Homologene
    FAMILY
  • microtubule affinity-regulating kinase (MARK)/Par-1 family
  • CATEGORY enzyme , receptor membrane kinase
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm
    text membrane localisation of MARK3 required a highly conserved C-terminal domain
    basic FUNCTION
  • kinase involved in the phosphorylation of microtubule-associated proteins
  • may be involved in cell cycle regulation, and its alterations may lead to carcinogenesis
  • positive regulator of the WNT-beta catenin signaling pathway
  • play a pivotal role in establishing cellular polarity
  • with MARK2, phosphorylate class IIa HDACs on one of their multiple 14-3-3 binding sites and alter their subcellular localization and repressive function
  • MARK1, MARK2, MARK3, MARK4 phosphorylate MAPT in its repeat domain and thereby regulate its affinity for microtubules and affect the aggregation of tau into Alzheimer paired helical filaments
  • potentially a positive regulator for lipogenesis in adipocytes and hepatocytes
  • MARK1, MARK2, MARK3, MARK4 are implicated in phosphorylation of tau protein, causing formation of neurofibrillary tangles in Alzheimer disease (AD)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • binds to CDC25C and phosphorylates CDC25C on serine-216
  • cell & other
    REGULATION
    Other phosphorylated by STK11
    regulated by 14-3-3 scaffolding proteins, as well as the LKB1 tumour suppressor kinase and atypical protein kinase C (PKC)
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • Par-1a/ mice are viable and develop normally, and adult mice are hypermetabolic, have decreased white and brown adipose tissue mass, and unaltered glucose/insulin handling, but show resistance to glucose intolerance on high-fat diet, and diet-dependent reduced adiposity
  • Par-1b/Par-1a double mutants are not viable, and at least one allele is necessary for embryonic survival