basic FUNCTION
| kinase involved in the phosphorylation of microtubule-associated proteins |
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may be involved in cell cycle regulation, and its alterations may lead to carcinogenesis |
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positive regulator of the WNT-beta catenin signaling pathway |
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play a pivotal role in establishing cellular polarity |
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with MARK2, phosphorylate class IIa HDACs on one of their multiple 14-3-3 binding sites and alter their subcellular localization and repressive function |
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MARK1, MARK2, MARK3, MARK4 phosphorylate MAPT in its repeat domain and thereby regulate its affinity for microtubules and affect the aggregation of tau into Alzheimer paired helical filaments |
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potentially a positive regulator for lipogenesis in adipocytes and hepatocytes |
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MARK1, MARK2, MARK3, MARK4 are implicated in phosphorylation of tau protein, causing formation of neurofibrillary tangles in Alzheimer disease (AD) |