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FLASH GENE
Symbol NEUROD4 contributors: mct - updated : 11-06-2012
HGNC name neurogenic differentiation 4
HGNC id 13802
EXPRESSION
Type restricted
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Visualeye    
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
basic helix-loop-helix (HLH) protein
HOMOLOGY
interspecies ortholog to murine Mtoh3
Homologene
FAMILY
CATEGORY DNA associated , transcription factor
SUBCELLULAR LOCALIZATION     intracellular
intracellular,nucleus,chromatin/chromosome
basic FUNCTION
  • converting undetermined or non-neural cells into neural cells
  • promote branchiomotor neuron development but also regulate the subsequent oligodendrocyte development and the cytoarchitecture by maintaining neural progenitors through Notch signaling
  • involved in CNTF-mediated differentiation of the late retinal progenitors
  • playing an essential, but not sufficient, role for amacrine cell genesis
  • possible redundant roles for NEUROD2 and NEUROD4 in pancreatic endocrine differentiation
  • dorsally restricted NEUROG2 transcriptional target and cofactor, which synergizes with NEUROG2 to accelerate target gene transcription in the cortex
  • CELLULAR PROCESS nucleotide, transcription
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • targeting MYT1, NHLH1, EBF3, EBF2, HES6, CBFA2T2, NEUROD1 (bind these enhancers to activate targets that execute core programs regulating neurogenesis)
  • TFAP2C directly regulated the basal progenitor fate determinants NEUROD4 and EOMES
  • ISL1 binds to a known POU4F1-regulated enhancer in the NEUROD4 gene, suggesting a mechanism of interaction between these genes
  • NEUROD4 and NEUROD6 are factors that are closely related to NEUROD1 and NEUROD2
  • cell & other
    REGULATION
    induced by NEUROG3
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility to maturity-onset diabetes of the young (MODY)
    Variant & Polymorphism other polymorphisms increasing the risk of maturity-onset diabetes of the young
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS