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FLASH GENE
Symbol B4GALT2 contributors: mct/npt - updated : 01-12-2015
HGNC name UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 2
HGNC id 925
EXPRESSION
Type ubiquitous
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveintestine    
Reproductivefemale systemuteruscervix highly
 female systemovary   
 male systemtestis   
Respiratoryrespiratory tractlarynx  highly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Muscular    
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a N terminal hydrophobic signal sequence
    • conjugated GlycoP
    HOMOLOGY
    Homologene
    FAMILY
  • beta-4- galactosyltransferase family
    • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,Golgi
    text
  • trans Golgi
  • type II transmembrane glycoprotein
    • basic FUNCTION
  • synthesis of N acetylactosamine in glycolipids and glycoproteins
  • one of the enzymes transferring galactose to the terminal N-acetylglucosamine of complex-type N-glycans and its expression is significantly altered during oncogenesis
  • play important roles in the extension of N- and O-linked glycans involved in several biological events
  • major regulator of the synthesis of glycans involved in neuronal development
  • specific enzyme complex of B4GALT2 with B3GAT1 plays an important role in the biosynthesis of B3GAT1 carbohydrate
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism carbohydrate
    signaling
    glycosylation
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • alpha lactalbumin
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS