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FLASH GENE
Symbol POLE2 contributors: mct - updated : 17-11-2015
HGNC name polymerase (DNA directed), epsilon 2 (p59 subunit)
HGNC id 9178
EXPRESSION
Type ubiquitous
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Lymphoid/Immunelymph node   highly
Reproductivefemale systemuterus  highly
Urinarybladder   highly
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • part of the N-terminal region (comprising AA 85-250) was found to be responsible for the interaction with SAP18, and N-terminal catalytic domain is solely responsible for its ability to catalyze DNA synthesis
    • HOMOLOGY
    interspecies homolog to yeast dpb2
    Homologene
    FAMILY DNA polymerase epsilon subunit b family
    CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,nucleoplasm
    basic FUNCTION
  • potential adaptor between the catalytic subunit and other accessory proteins
  • participates in DNA repair and in chromosomal DNA replication
  • may recruit histone deacetylase (HDAC) to the replication fork to modify the chromatin structure
    • CELLULAR PROCESS nucleotide, replication
    nucleotide, repair
    PHYSIOLOGICAL PROCESS
    text nuclear genome
    PATHWAY
    metabolism
    signaling
    a component four subunits: POLE1, POLE2, POLE3 and POLE4
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with SAP18 (interaction induced repression of transcription)
    • cell & other
    REGULATION
    Other regulated by 2 E2F -pocket protein complexes,one associated with sp1 and the other with NF1
    ASSOCIATED DISORDERS
    corresponding disease(s) SCIDP
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS