SUBCELLULAR LOCALIZATION
| intracellular
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| intracellular,cytoplasm,organelle,mitochondria,inner
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| intracellular,cytoplasm,organelle,membrane
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| intracellular,nucleus,nucleoplasm,nuclear bodies
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text
| 24is an AAA protease that is embedded in the mitochondrial inner membrane with its catalytic domain facing the mitochondrial inner-membrane space |
basic FUNCTION
| putative ATP-dependent protease involved in the degradation of unassembled COX2 subunit |
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putative proteolytic and chaperone-like activities at the inner mitochondrial membrane |
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plays a phylogenetically conserved role in mitochondrial protein metabolism and could be involved in mitochondrial pathologies |
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involved in peptide generation in the intermembrane space and led to the induction of nuclear genes with functions in mitochondrial gene expression and the biogenesis of the respiratory chain |
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novel role for YME1L1 in the proteolytic regulation of respiratory chain biogenesis |
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is a stress-sensitive mitochondrial protease that is rapidly degraded in response to acute oxidative stress |
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stress-induced YME1L1 degradation is a biologic process that attenuates protective regulation of mitochondrial proteostasis and promotes cellular death in response to oxidative stress |
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YME1L1 and OMA1 are critical regulators of essential mitochondrial functions, including inner membrane proteostasis maintenance and mitochondrial dynamics |