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FLASH GENE
Symbol DNAJC7 contributors: mct - updated : 22-08-2014
HGNC name DnaJ (Hsp40) homolog, subfamily C, member 7
HGNC id 12392
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Nervousbrainmidbrain  predominantly
 brain   predominantly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Nervouscentral   
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • nine tetratricopeptide repeats
  • a region of similarity with the DnaJ protein family
  • and a coiled coil domain within the TPR domain
  • two N-terminal tetratricopeptide repeat domains
  • a C-terminal DNAJ domain
  • HOMOLOGY
    interspecies homolog to murine Dnajc7
    homolog to Drosophila Tpr2
    intraspecies homolog to PRKP1
    Homologene
    FAMILY
    CATEGORY chaperone/stress
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,cytoskeleton
    intracellular,nucleus
    basic FUNCTION
  • implicated in steroid receptor chaperoning
  • participates in TP53/MDM2 negative feedback regulatory pathway, and thereby enhancing the stability and activity of TP53
  • has an ability to enhance TP53-dependent transcriptional activation
  • CELLULAR PROCESS protein, post translation, folding
    PHYSIOLOGICAL PROCESS development
    text preventing protein aggregation
    PATHWAY
    metabolism
    signaling
    a component
  • DNAJC7 directly interacts with the ligand-binding domain of NR1I3 and mediates the formation of a cytoplasmic NR1I3-DNAJC7-HSP90 ternary complex
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • binding to GAP-related domain of NF1,via its TPR region
  • DNAJC7 is associated with TP53 in mammalian cells
  • ubiquitin-proteasomal regulation of DNAJC7 and HSPA4 are important contributors to the regulation of cytoplasmic NR1I3 levels
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS