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FLASH GENE
Symbol CAPN5 contributors: mct - updated : 11-07-2017
HGNC name calpain 5
HGNC id 1482
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveintestinesmall intestine  highly
 intestinelarge intestinecolon specific
Endocrineneuroendocrinepituitary  highly
Nervousbraindiencephalonhypothalamus highly Homo sapiens
 brainhindbraincerebellum highly
Visualeyeretina    Homo sapiens
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Nervouscentral    Homo sapiens
cells
SystemCellPubmedSpeciesStageRna symbol
Olfactoryolfactory receptor
Visualcone photoreceptor Homo sapiens
Visualrod photoreceptor Homo sapiens
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • N terminal regulatory domain processed after activation, and an N-terminal monopartite NLS
  • protein domain (II), linker (III)
  • C terminal T domain (not containing a calmodulin-like EF hand motifs), and a unique bipartite NLS closer to the C terminus; C-terminal NLS contains a SUMO-interacting motif that contributes to nuclear localization, and mutation or deletion of both NLS renders CAPN5 exclusively cytosolic
  • mono polymer heteromer , dimer
    HOMOLOGY
    interspecies homolog to C.elegans sex determination gene tra3
    Homologene
    FAMILY
  • papain superfamily, nCL-3 type
  • olfactory marker protein family
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    intracellular,nucleus
    basic FUNCTION
  • calcium dependent neutral cysteine proteinase (non lysosomal)
  • may act as a modulator of the olfactory signal- transduction cascade
  • calcium-activated cysteine protease
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    text signal transduction
    PATHWAY
    metabolism
    signaling signal transduction
    a component heterodimerezing with a small subunit
    INTERACTION
    DNA
    RNA
    small molecule metal binding,
    calcium Ca2+
    protein
  • interacts with BEX1 and BEX2
  • CAPN5 is a target of HOXA10 transcriptional regulation in endometrial cells
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --low  
    in both stromal and glandular cells from women with endometriosis compared with that of fertile controls
    Susceptibility to polycystic ovary syndrome
    Variant & Polymorphism other GGCA and GGTG were overrepresented in polycystic ovary syndrome patients
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS