Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol RRP8 contributors: mct/npt - updated : 05-10-2016
HGNC name ribosomal RNA processing 8, methyltransferase, homolog (yeast)
HGNC id 29030
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
blood / hematopoieticspleen    
Digestiveliver    
Endocrinepancreas    
Nervousbrain    
Reproductivemale systemprostate   
Respiratorylung    
Urinarykidney    
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Epithelialsecretoryglandularendocrine 
Epithelialsecretoryglandularexocrine 
Lymphoid    
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • motifs found in methyltransferases (Bousquet-Antonelli 2000)
    • HOMOLOGY
    interspecies homolog to yeast S.pombe C56F8-09 protein
    homolog to Drosophila CG7137
    homolog to C.elegans T07A9.8
    Homologene
    FAMILY
  • methyltransferase superfamily
  • RRP8 family
    • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    intracellular,nucleus,nucleoplasm
    intracellular,nucleus,nucleolus
    text localizes to the nucleolus (Bousquet-Antonelli 2000)
    basic FUNCTION
  • methyltransferase activity
  • nucleolar protein functionally linked to GAR1 and involved in pre-rRNA cleavage at site A2 (Bousquet-Antonelli 2000)
  • nucleolar protein, important for mediating the assembly of the energy-dependent nucleolar silencing complex (eNoSC), which also contains SIRT1 and SUV39H1
  • RRP8 complex promotes rDNA heterochromatin formation and represses rRNA transcription
  • is required for the N(1)-methyladenosine (m(1)A) modification in 28S rRNAs of human cells
  • also contributes to 60S ribosomal subunit formation
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • NMNAT1 interacts with the nucleolar repressor protein RRP8 and is involved in regulating rRNA transcription
  • RRP8-SIRT1 interaction was competitively inhibited by rRNA
  • RRP8-mediated rRNA base methylation links ribosomal subunit formation to cell proliferation in a TP53-dependent manner
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS