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FLASH GENE
Symbol ATG2A contributors: mct - updated : 25-01-2014
HGNC name ATG2 autophagy related 2 homolog A (S. cerevisiae)
HGNC id 29028
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • N-terminal fragment were sufficient for preautophagosomal structure (PAS) recruitment but were not sufficient to function in autophagy
  • HOMOLOGY
    interspecies homolog to C.elegans cosmid M03A8
    Homologene
    FAMILY
    CATEGORY unknown/unspecified
    SUBCELLULAR LOCALIZATION
    text
  • localizes on the autophagic membrane, as well as on the surface of lipid droplets
  • basic FUNCTION
  • ATG2A, ATG2B proteins function both in autophagosome formation and regulation of lipid droplet morphology and dispersion
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional        
    simultaneous silencing of ATG2A and ATG2B causes a block in autophagic flux and accumulation of unclosed autophagic structures containing most ATG proteins
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS