basic FUNCTION
| ADP ribosylation factor (ARF) GTPase activating protein,phosphatidyl 4,5 biphosphate (PIP2)-dependent |
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regulator and coordinator of cell growth, actin cytoskeletal organization and ARF nucleotide cycle |
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cycling with FA proteins when cells are stimulated to move |
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enzyme activator |
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present in cell structures required for cell migration and invasion, such as focal adhesions, invadopodias, and podosomes, and are involved in endocytosis and cytoskeletal remodeling (Ismail 2010) |
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involvement in carcinogenesis and metastasis highlights the importance of the presented structure in general and the Ca2+-binding pocket in particular as it may give clues for designing inhibitors for therapeutic applications (Ismail 2010) |
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ASAP2 is a new target of SELK-dependent palmitoylation |
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ASAP2 is a novel druggable driver gene that activates the EGFR signaling pathway |