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FLASH GENE
Symbol ASAP2 contributors: mct/npt - updated : 06-02-2024
HGNC name ArfGAP with SH3 domain, ankyrin repeat and PH domain 2
HGNC id 2721
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart    
Digestivemouth   highly
 stomach   highly
Endocrinepancreas    
Nervousbrain    
Respiratoryrespiratory tractlarynx  highly
Urinarykidney    
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period pregnancy
Text placenta
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • from the N terminus, a pleckstrin homology domain PH
  • a GAP domain that includes a zinc finger motif
  • three ankyrin repeats
  • a Bin/Amphiphysin/Rvs (BAR) domain
  • a proline-rich region with alternative splicing and SH3 binding domains
  • eight repeats of the sequence E/DLPPKP and a C terminal SH3 domain, binding SAMP motif of APC specifically (Matsui 2008)
  • HOMOLOGY
    Homologene
    FAMILY
  • ArfGAP family
  • CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,Golgi
    intracellular,cytoplasm,cytosolic
    text localizing to focal adhesions
    basic FUNCTION
  • ADP ribosylation factor (ARF) GTPase activating protein,phosphatidyl 4,5 biphosphate (PIP2)-dependent
  • regulator and coordinator of cell growth, actin cytoskeletal organization and ARF nucleotide cycle
  • cycling with FA proteins when cells are stimulated to move
  • enzyme activator
  • present in cell structures required for cell migration and invasion, such as focal adhesions, invadopodias, and podosomes, and are involved in endocytosis and cytoskeletal remodeling (Ismail 2010)
  • involvement in carcinogenesis and metastasis highlights the importance of the presented structure in general and the Ca2+-binding pocket in particular as it may give clues for designing inhibitors for therapeutic applications (Ismail 2010)
  • ASAP2 is a new target of SELK-dependent palmitoylation
  • ASAP2 is a novel druggable driver gene that activates the EGFR signaling pathway
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS development
    PATHWAY
    metabolism
    signaling
    a component
  • associated with and phosphorylated by SRC
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • GTPase activating protein for ARF1, ARF6
  • DDEF1 (ASAP1)
  • is a primary target of 1,25-dihydroxyvitamin D3 in human monocytes and macrophages
  • interactions between SELK and ASAP2, SELK was required for ASAP2 to be cleaved by calpain-2 within the Bin/Amphiphysin/Rvs (BAR) domain of ASAP2
  • binds to SH3KBP1 and CBL, but undergoes mostly polyubiquitination
  • ASAP2 is an ARL15-interacting protein
  • cell & other
  • inhibiting the formation of PDGF-induced dorsal membrane ruffles in NIH 3T3 fibroblasts, when overexpressed
  • REGULATION
    Other phosphorylated by SRC
    targeted by PYK2
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    contributed to a poor prognosis in pancreatic ductal adenocarcinoma (PDAC)
    tumoral     --over  
    in hepatocellular carcinoma (HCC) tissues than in normal liver, and also predicted poor prognosis
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    immunologyinfectious 
    may serve as a potential treatment target against virus infections
    immunologyinflammatory 
    may serve as a potential treatment target against inflammatory diseases
    ANIMAL & CELL MODELS