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FLASH GENE
Symbol NUPL2 contributors: mct - updated : 08-03-2008
HGNC name nucleoporin like 2
HGNC id 17010
EXPRESSION
Type ubiquitous
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Hearing/Equilibriumearinnercochlea highly
Nervousnerve   highly
Reproductivefemale systemovary   
Urinarybladder   highly
Visualeye    
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a putative zinc finger, CCCH type
  • a C3H1-type zinc finger
  • HOMOLOGY
    interspecies homolog to murine Nupl2
    Homologene
    FAMILY
    CATEGORY signaling , transport
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    intracellular,nucleus
    basic FUNCTION
  • porin activity
  • participates in the docking of HIV-Vpr at the nuclear envelope, which may contribute to the disruption of the nuclear envelope import of the viral DNA
  • required for the export of mRNAs containing poly(A) tails from the nucleus into the cytoplasm
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling sensory transduction/hearing
    a component NUP155, GLE1, and nucleoporin NUPL2 form a heterotrimeric complex (Zhang 2008)
    INTERACTION
    DNA binding
    RNA
    small molecule
    protein
  • interacts with CRM1
  • interacts with the Rev nuclear export signal
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS