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FLASH GENE
Symbol ARHGAP4 contributors: mct - updated : 17-02-2010
HGNC name Rho GTPase activating protein 4
HGNC id 674
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
blood / hematopoieticspleen    
 thymus    
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Blood / hematopoieticplasma  highly
Lymphoid    
cells
SystemCellPubmedSpeciesStageRna symbol
Blood/Hematopoieticleukocyte
cell lineage hematopoietic cells
cell lines
fluid/secretion
at STAGE
physiological period fetal, pregnancy
Text placenta, lung
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a N terminal Fes/CIP homology (FCH), important for spatially localizing ARHGAP4 to axon growth cones
  • a central RHO-GAP (GAP domain and C-terminus are necessary for ARHGAP4-mediated inhibition of cell and axon motility)
  • a FBH domain
  • a C terminal SH3 domains
  • HOMOLOGY
    interspecies homolog to C.elegans F12F6.5
    Homologene
    FAMILY
  • FNBP2 protein family
  • RhoGAP family
  • CATEGORY adaptor , regulatory , signaling
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    intracellular,nucleus
    basic FUNCTION
  • inhibitory effect on stress fiber organization, may be down regulating Rho-like GTPase in hematopoietic cells
  • can act as a potent inhibitor of cell and axon motility when it is localized to the leading edge of motile cells and axons
  • may play some role in lymphocyte differentiation but partial loss of ARHGAP4 does not result in clinical immunodeficiency
  • CELLULAR PROCESS cell organization/biogenesis
    PHYSIOLOGICAL PROCESS
    text cytoskeletal regulation
    PATHWAY
    metabolism
    signaling signal transduction
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional   deletion    
    contiguous gene syndrome of severe combined immunodeficiency and nephrogenic diabetes insipidus in Xq28 deletion encompassing AVPR2 and ARD1A
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    bloodhemoglobin 
    may represent potential tools for the identification of new targets for sickle cell anaemia therapy
    ANIMAL & CELL MODELS