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FLASH GENE
Symbol CSNK1G2 contributors: npt - updated : 14-06-2002
HGNC name casein kinase 1, gamma 2
HGNC id 2455
EXPRESSION
Type widely
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestivesalivary gland   highly
Endocrineadrenal gland   highly
Nervousnerve   highly
Reproductivemale systemtestis  predominantly
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a channel proline-rich sequence
  • a SH3 domain
  • a characteristic CKSG signature at C terminus
  • conjugated PhosphoP
    mono polymer monomer
    isoforms Precursor
    HOMOLOGY
    Homologene
    FAMILY
  • protein kinase superfamily
  • CK1 Ser/Thr protein kinase family
  • casein kinase I subfamily
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    basic FUNCTION
  • casein kinase 1, may be involved in signaling pathways downstream of RTKS
  • phosphorylates and modulates the functions of MTA1, and that these extranuclear effects of estrogen might have important implications in regulating the functions of MTA1 in mammary epithelial and cancer cells
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling signal transduction
    a component
    INTERACTION
    DNA
    RNA
    small molecule nucleotide,
  • ATP
  • protein
  • interacting with the SH3 domain of the adapter proteins NCK1 or NCK2
  • preferentially acidic proteins, broad specificity
  • bind to PER1 and to promote its degradation
  • MTA1-binding protein
  • cell & other
    REGULATION
    induced by estrogen that stimulates its activity , effectively blocked by a specific inhibitor of CKI
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS