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FLASH GENE
Symbol EIF3E contributors: mct/npt - updated : 19-02-2019
HGNC name eukaryotic translation initiation factor 3, subunit E
HGNC id 3277
EXPRESSION
Type ubiquitous
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestivepharynx   highly
 salivary gland   highly
Endocrineneuroendocrinepituitary   
Hearing/Equilibriumearinnercochlea highly
Urinarybladder   highly
cell lineage
cell lines Hela cells
fluid/secretion
at STAGE
physiological period embryo
Text neural crest, notocord, cartilage
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a PCI (PINT) proteasome (Int-6, Nip-1, TRIP15) motif
  • HOMOLOGY
    interspecies ortholog to murine Int-6
    Homologene
    FAMILY
  • eukaryotic translation initiation factor family
  • CATEGORY RNA associated , protooncogene
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,Golgi
    intracellular,cytoplasm,cytosolic,ribosome
    intracellular,nucleus,nucleoplasm,nuclear bodies,nuclear speckles
    intracellular,nucleus,nucleoplasm,nuclear bodies,PML
    basic FUNCTION
  • stabilizing initiator Met tRNA (TRIMs) binding to 40S subunits
  • promoting the association of Met-tRNA and mRNA
  • involved in association with eIF3, in routing specific mRNAs for degradation
  • involved in the quality control of specific mRNAs, the abundance of which is regulated by nonsense-mediated mRNA decay (NMD)
  • stabilizes chromatin-bound MCM7 and alteration of this effect is associated with replication deficiency (Buchsbaum 2007)
  • CELLULAR PROCESS protein, translation/synthesis
    PHYSIOLOGICAL PROCESS
    text regulation of translation
    PATHWAY
    metabolism
    signaling
    a component
  • components of the EIF3 multiprotein complex, 600kDa, subunit (EIF3E) of the eukaryotic translation initiation factor EIF3
  • component of the 26S proteosome
  • component of the COP9 signalosome, 450kDa
  • INTERACTION
    DNA
    RNA binding to the 40S ribosome
    small molecule
    protein
  • EIF3SIP
  • interaction with MCM7 (removal of MCM7 from chromatin as replication proceeds was accelerated in EIF3E-silenced cells and reduced amounts of protein were transiently observed, followed by a correction resulting from stimulation of MCM7 gene expression)(Buchsbaum 2007)
  • EIF4G1 protein binds to EIF3C, EIF3D, and EIF3D to promote mRNA recruitment to the ribosome
  • cell & other
    REGULATION
    Other excluded from PML nuclear bodies by binding to the HTLV-1 oncoprotein
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral   deletion    
    of ten deleted in primary breast carcinoma
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS