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FLASH GENE
Symbol UTY contributors: mct - updated : 29-12-2016
HGNC name ubiquitously transcribed tetratricopeptide repeat gene, Y-linked
HGNC id 12638
EXPRESSION
Type ubiquitous
   expressed in (based on citations)
organ(s)
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • five tetratricopeptide motis
  • HOMOLOGY
    interspecies homolog to murine Uty
    homolog to C.elegans d2021.1
    intraspecies paralog to KDM6A
    Homologene
    FAMILY
  • UTX family
  • CATEGORY enzyme , antigen
    SUBCELLULAR LOCALIZATION extracellular
        intracellular
    intracellular,nucleus,nucleoplasm
    basic FUNCTION
  • minor histocompatibility antigen which may induce graft rejection of male stem cell grafts
  • lacking detectable demethylase activity, compensates for the loss of KDM6A in regulating Brachyury expression
  • catalyzes demethylation of H3K27 peptides, analogously to KDM6B and KDM6A, but with reduced activity, due to point substitutions involved in substrate binding
  • NKX3.1-G9a-UTY transcriptional regulatory network is essential for prostate differentiation, and likely disruption of such a network predisposes to prostate cancer
  • both KDM6A and UTY function as dose-dependent suppressors of urothelial bladder cancer (UBC) development
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS immunity/defense , reproduction/sex
    text anti-pathogen response ; male specific development, spermatogenesis
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • with TLE1 and TLE2
  • KDM6A controls mesoderm differentiation and Brachyury (T) expression independent of H3K27 demethylase activity, suggesting that KDM6A and UTY are functionally redundant in ES cell differentiation and early embryonic development
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS