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FLASH GENE
Symbol PSME1 contributors: mct/npt - updated : 10-07-2008
HGNC name proteasome (prosome, macropain) activator subunit 1 (PA28 alpha)
HGNC id 9568
EXPRESSION
Type ubiquitous
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestivepharynx   highly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Blood / hematopoieticbone marrow  highly
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • the KEKE motif promoting binding of protein with this structural feature
  • mono polymer homomer , heteromer , dimer , heptamer
    HOMOLOGY
    interspecies homolog to murine Psme1
    homolog to rattus Psme1
    intraspecies homolog to Ki antigen
    Homologene
    FAMILY
  • PSM, proteasome
  • PA28 family
  • CATEGORY chaperone/stress , regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    basic FUNCTION
  • implicated in immunoproteasome assembly and required for efficient antigen processing
  • plays an important role in the generation of MHC ligands by proteasomes
  • the PA28 activator complex enhances the generation of class I binding peptides by altering the cleavage pattern of the proteasome
  • involved in the presentation of endogenous antigens by MHC class I molecules
  • its function is particularly relevant for the generation of normally poorly excised peptide products
  • CELLULAR PROCESS protein, degradation
    protein, ubiquitin dependent proteolysis
    PHYSIOLOGICAL PROCESS immunity/defense
    PATHWAY
    metabolism
    signaling
    a component
  • component 260 S proteasome hexameric activator
  • heterodimer of PSME1 and PSME2 forming a hexadimeric ring
  • able to form homoheptamers
  • ATP dependent association of PA28 and proteasome
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • PSME1
  • PSME2
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
    Pa28 knockout mice