Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol THBS3 contributors: mct - updated : 21-08-2013
HGNC name thrombospondin 3
HGNC id 11787
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheartvalve    Homo sapiens
Digestivestomach   highly
Reproductivemale systemtestis  highly
Respiratorylung   highly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Connectivebone  highly
Epithelialbarrier/lining   
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES acid
STRUCTURE
motifs/domains
  • four type II (EGF-like)
  • seven type III (Ca++ binding) repeats
  • a TSP C-terminal (TSPC) domain
  • a TSP N-terminal (TSPN) domain
  • conjugated GlycoP
    mono polymer pentamer
    HOMOLOGY
    interspecies homolog to murine Thbs3
    Homologene
    FAMILY thrombospondin family
    CATEGORY adhesion
    SUBCELLULAR LOCALIZATION extracellular
    intracellular,nuclear envelope
    basic FUNCTION
  • playing a unique role in cell matrix interactions
  • adhesive glycoprotein that mediates cell-to-cell and cell-to-matrix interactions
  • highly conserved matricellular protein regulating inflammation, angiogenesis and extracellular matrix remodeling
  • CELLULAR PROCESS cell communication
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component oligomer disulfide-linked
    INTERACTION
    DNA
    RNA
    small molecule
    protein bind to fibrinogen, fibronectin, laminin and type V collagen
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS