SUBCELLULAR LOCALIZATION
| intracellular
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| intracellular,cytoplasm,organelle,membrane
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| intracellular,cytoplasm,organelle,peroxisome
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| intracellular,cytoplasm,cytosolic
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| intracellular,nucleus,nucleoplasm
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text
| attached to the outer surface of peroxisomes |
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associated with theendoplasmic reticulum |
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PEX19 was partly localized to peroxisomes but mostly localized in the cytosol |
basic FUNCTION
| involved in the process of peroxisomal biogenesis or assembly |
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a central role in the early steps of peroxisomal membrane synthesis |
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required for the import of peroxisome membrane proteins (class 1 exclusively) from cytoplasm to peroxisome |
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involved in the intracellular sorting and trafficking of ALDP, PMP70, and ALDRP proteins |
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might function as a PMP-specific chaperone, a cycling peroxisomal membrane proteins(PMP)-receptor protein, a PMP membrane insertion factor, or an association/dissociation factor of membrane-associated protein complexes |
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binds to the docking and assembly complex Pex13p/Pex14p, indicating a functional role in the formation of a multi-component importomer complex |
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farnesylation of PEX19 is required for its structural integrity and function in peroxisome biogenesis |
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functions as a receptor and chaperone of peroxisomal membrane proteins |
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PEX3 and PEX19 are essential for peroxisome biogenesis |
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PEX19 formed a complex with the peroxisomal Tail-anchored (TA) protein PEX26 in the cytosol and translocated it directly to peroxisomes by interacting with the peroxisomal membrane protein PEX3 |
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in peroxisomes, peroxins PEX3 and PEX19 are the principal protein components of the machinery required for early peroxisomal biogenesis |
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transport of peroxisomal membrane proteins (PMPs) requires the soluble PEX19 protein as chaperone and import receptor |
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harbouring a prenylation CAAX box functions as a chaperone and transporter for peroxisomal membrane proteins in membrane assembly |
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PEX19 and PEX3 play an indispensable role in peroxisomal membrane protein (PMP) biogenesis, peroxisome division, and inheritance |
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PEX3, an integral peroxisomal membrane protein, and the cytosolic shuttling receptor PEX19 are thought to be responsible for the early steps of peroxisome biogenesis and assembly of their matrix protein import machinery |