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FLASH GENE

Symbol

SCN2B

contributors: mct/ - updated : 05-07-2004

HGNC name	sodium channel, voltage-gated, type II, beta
HGNC id	10589

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

EXPRESSION

Type

constitutive of

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Cardiovascular heart         Nervous brain         Visual eye

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Connective bone

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	a N terminal large extracellular domain containing a Ig-V type fold with a disulfide bond and four N-linked glycosylation sites
	a single transmembrane segment
	a short intracytoplasmic C terminal tail

HOMOLOGY

interspecies

homolog to rattus contactin (with human auxilliary subunit beta)

intraspecies

homolog to myelin protein zero, highly

Homologene

FAMILY

sodium channel auxiliary subunit SCN2B family

CATEGORY

transport channel

SUBCELLULAR LOCALIZATION

plasma membrane

basic FUNCTION

sodium channel, voltage-gated, type II,involved in the initiation and conduction of electrical impulses in nerves

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

protein constituent of membrane

INTERACTION

DNA

RNA

small molecule

protein

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function constitutional     --low   age-down regulated in the frontal cortex

Susceptibility

to atrial fibrillation

Variant & Polymorphism SNP	R28Q, R28W associated with atrial fibrillation (Watanabe 2009)

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS