basic FUNCTION
| growth suppressor |
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regulation of DNA replication |
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plays an essential role in the early stage of embryogenesis and has a potential role during craniofacial morphogenesis |
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CDK2AP1 exerts its effect on stem cell |
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maintenance/differentiation through epigenetic regulation |
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plays likely an important role in modulating the growth and tumorigenesis of lung cancer cells and also has significant effects on the chemosensitivity of pulmonary malignancies |
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tumor suppressor that plays a role in cell cycle regulation by sequestering monomeric CDK2, and targeting it for proteolysis |
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knockdown of CDK2AP1 in primary human fibroblasts reduced proliferation and induced premature senescence, with the observed phenotype being TP53 dependent |