protein
| NPHP4, NPHP3, INVS |
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interacting with BCAR1, PTK2B, tensin and filamin |
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interacting with TNK2 (implicating cell |
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/cell junctions and the renal collecting duct in the pathology of nephronophthisis) |
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interacting with NPHS1 and PARD3 (interaction mediated through the PDZ domain of PARD3 and conserved carboxyl terminal residues in NPHP1 and NPHS1, and essential for establishing the three-dimensional architecture of podocytes at the kidney filtration barrier) |
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TNK2 is a novel interaction partner of nephrocystin-1 and implicate cell-cell junctions and the renal collecting duct in the pathology of nephronophthisis |
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interaction between the PKD1 polyproline motif and the NPHP1 SH3 domain |
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NPHP1 and nephrocystin-4 (NPHP4) interact and NPHP4 negatively regulates tyrosine phosphorylation of NPHP1 |
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interaction of NPHP1/PACS1 is negatively regulated by NPHP4 |
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JADE1 colocalizes with NPHP1 at the transition zone of primary cilia and interacts with NPHP4 |
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INVS, NPHP1 can interfere with ciliary disassembly through interaction with the AURKA module, thereby modulating cell cycle control and cell proliferation |
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interacts genetically with AHI1 |
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ZNF131 activity notably promotes expression of Joubert Syndrome ciliopathy genes, including KIF7, NPHP1, and TMEM237, as well as HAUS5, a component of Augmin/HAUS complex that facilitates microtubule nucleation along the mitotic spindle |